Transcriptome profiling to identify a human effector regulatory T cell core signature

We investigated the transcriptomic landscape of human Treg in an autoimmune-associated inflammatory environment, i.e. synovial fluid (SF) from inflamed joints of Juvenile Idiopathic Arthritis (JIA) to improve our understanding of human effector Treg programming. Examination of the regulatory and CD4 effector T cell transcriptome in 3-4 biological replicaties of each healthy adult and child peripheral blood, juvenile idiopathic arthritis patient peripheral blood in remission and with active disease as well as synovial fluid.