BIOGRID CURATED DATA FOR SCD-2 (Caenorhabditis elegans)

Protein-Protein, Genetic, and Chemical Interactions for SCD-2 (Caenorhabditis elegans) curated by BioGRID (https://thebiogrid.org); DEFINITION: scd-2 encodes the homolog of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) (OMIM:105590, involved in the development of non-Hodgkin's lymphoma in humans); the ALK family of receptor tyrosine kinases belong to the insulin receptor superfamily; scd-2 was initially identified in a naturally occuring desert oasis strain of C. elegans that fails to respond to the dauer pheromone at 25 degrees centigrade, but does so at a higher temperature; genetic interactions of scd-2 with several genes in the TGF-beta pathway including daf-7, daf-8 and daf-4 indicate that scd-2 acts in parallel to or converges with this pathway to regulate dauer formation via activation of the daf-3 transcription factor; further, genetic interaction studies indicate that the genes hen-1 (ortholog of the ALK ligand), soc-1 (RTK multi-adaptor protein related to DOS/Gab) and sma-5 (similar to human ERK5/MAP kinase 7) act along with scd-2 RTK in a chemosensory transduction pathway that converges with the TGF-beta pathway to affect the dauer decision.

SCD-2（线虫秀丽隐杆线虫）的蛋白质-蛋白质、遗传和化学相互作用数据集，由BioGRID（https://thebiogrid.org）编纂；定义：scd-2编码与间变性淋巴瘤激酶（ALK）受体酪氨酸激酶（RTK）同源的基因（OMIM:105590，与人类非霍奇金淋巴瘤的发生发展相关）；ALK受体酪氨酸激酶家族属于胰岛素受体超家族；scd-2最初在一种自然出现的沙漠绿洲菌株中鉴定，该菌株在25摄氏度时无法对dauer信息素做出反应，但在更高温度下则可以；scd-2与TGF-β通路中包括daf-7、daf-8和daf-4在内的多个基因的遗传相互作用表明，scd-2在此通路中平行作用或与该通路汇聚，通过激活daf-3转录因子调节dauer的形成；此外，遗传相互作用研究表明，基因hen-1（ALK配体的同源物）、soc-1（与DOS/Gab相关的RTK多适配蛋白）和sma-5（与人类ERK5/MAP激酶7相似）与scd-2 RTK共同作用于一种化学感应转导通路，该通路与TGF-β通路汇聚，影响dauer的决定。