Lactobacillus plantarum Zhang LL inhibits colitis related tumorigenesis

In this study, we constructed a mouse model of CRC using an intraperitoneal injection of azomethane combined with dextran sodium sulfate, while administering 5 fluorouracil as well as high and low doses of L. plantarum Zhang LL live or heat killed strains. To investigate the specific mechanisms involved in alleviating CRC progression, high-throughput sequencing technology was used to analyze the gut microbiota, nontargeted metabolomics of intestinal contents, and eukaryotic transcriptomics of intestinal tissues.