Crystal structure of BRD4(1) bound to the dual BET-HDAC inhibitor LSH24
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Crystal structure of BRD4(1) bound to the dual BET-HDAC inhibitor LSH24 Descriptor: 4-acetyl-3-ethyl-N-(3-(3-(hydroxyamino)-3-oxopropyl)phenyl)-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 Authors: Huegle, M. Deposit date: 2020-11-10 Release date: 2021-10-06 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.5 Å) Cite: 4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads. J.Med.Chem., 64, 2021
创建时间：
2020-11-10
