Adansonia Digitata (Baobab) Ameliorate thyroid Gland Disorder of Alloxan-Induced Diabetes Model

Diabetes and thyroid disorders have been shown to mutually influence each other because of the role of the thyroid gland in the regulation of body metabolism. This work is therefore designed to study the effect of aqueous leaf extract of Adansonia digitata (baobab) on the thyroid gland of alloxan-induced diabetes. Twenty-eight Wistar rats, weighing 120g to 195g were divided into seven groups (n=4). Sham control, Diabetes control, Diabetes + Low dose, Diabetes + High dose, Diabetes + metformin, Low dose, and High dose. Diabetes was induced with a single dose of 150mg/kg alloxan monohydrate and animals were treated with Adansonia digitata for 14 days. This study indicated that the leaf extract of Adansonia digitata increase serum triiodothyronine levels and reversed the histological damage to the thyroid gland. Therefore, Adansonia digitata could be used to manage metabolic dysfunctions in the diabetic thyroid gland