Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K541Q,K542Q,R543S,K545Q,K548Q,K579Q)-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... Authors

Protein Data Bank Japan2024-11-27 更新30

Crystal Structure of PF10_0086, adenylate kinase from plasmodium falciparum

疟原虫靶点结构

结构生物学

Crystal Structure of PF10_0086, adenylate kinase from plasmodium falciparum Descriptor: ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Wernimont, A.K, Loppn

Protein Data Bank Japan2024-02-28 更新20

Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with STZ-DHP

疟原虫靶点结构

疟疾抗药性

Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with STZ-DHP Descriptor: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 4-{[(2-amino-4-oxo-3,4,7,8-tetrahyd

Protein Data Bank Japan2023-11-22 更新30

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria

抗疟药物研发

疟原虫靶点结构

A novel 2,8-disubstituted-1,5-naphthyridine hit compound stemming from the open access Medicines for Malaria Venture Pathogen Box formed a basis for a hit-to-lead medicinal chemistry program. Structur

NIAID Data Ecosystem20

Structure of Plasmepsin X (PM10, PMX) from Plasmodium falciparum 3D7 in complex with UCB7362

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