RNA sequencing uncover crucial genes mediating progression of in large-artery atherosclerotic and small-artery occlusion ischemic stroke

The goal of our study is to uncover the pathogenesis of large-artery atherosclerotic ischemic stroke (LAAIS) and small-artery occlusion ischemic stroke (SAOIS) and analyze their difference using RNA sequencing.RNA sequencing was used to filtrate differentially expressed mRNAs (DEmRNAs) and lncRNAs (DElncRNAs) in LAAIS and SAOIS. Specific DEmRNAs and DElncRNAs in LAAIS and SAOIS were further foun. Functional annotation and DElncRNA-DEmRNA co-expression network was built to reveal biological function of DEmRNAs. Overall design: The cohort subjected to RNA-Seq consisted 3 LAAIS patients , 3 SAOIS patients and 3 healthy individuals.