Treating pain in sickle cell disease by means of focused ultrasound neuromodulation (Intracranial recordings)

We have demonstrated a novel transcranial focused ultrasound technology for pain treatment, that promises to provide non-pharmacologic chronic pain treatment for patients associated with underlying conditions such as cancer or sickle cell disease (SCD).The Intracranial recordings were conducted from 2 experimental in vivo mice. This work was supported in part by NIH EB029354, NS124564, and NS131069. Animal care and handling are according to the regulation of Institutional Animal Care and Use Committee of Carnegie Mellon University and complied with National Institutes of Health guidelines. More information can be found in the corresponding manuscript:Kim MG*, Yu K*, Yeh C-Y, Fouda R, Argueta D, Kiven S, Ni Y, Niu X, Chen Q, Kim K, Gupta K, He B. Low-intensity transcranial focused ultrasound changes pain-associated behaviors by modulating pain processing brain circuits. bioRxiv: https://doi.org/10.1101/2022.12.07.519518 (*Equal contribution, first author)If anyone uses the whole or part of the dataset provided here, we kindly ask you to cite the above publication in any of your publications or presentations: