Expression data from children and adolescents treated with Fluoxetine

It is well-known that between 40 and 50% of patients taking antidepressants do not respond to treatment or relapse. Genome wide gene expression studies can help us to understand better the response to antidepressants, revealing the effects of both genetic background and environmental/epigenetic factors. We used microarrays to detail the response to Fluoxetine in children and adolescents, analysing the expression just before intake of drug and 8 weeks after starting the treatment. RNA extraction was done from blood of patients. Two samples of each patient were obtained, one previous to treatment and another 8 weeks later. The samples with better quality were selected for hybridization and Affymetrix microarrays.