EGFR(T790M/V948R) in complex with a macrocyclic inhibitor
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EGFR(T790M/V948R) in complex with a macrocyclic inhibitor Descriptor: 19-chloro-18-fluoro-22-methoxy-8,9,11,12,14,15-hexahydro-21H-4,6-ethenopyrimido[5,4-m][1,4,7,10,15]benzotetraoxazacycloheptadecine, Epidermal growth factor receptor Authors: Beyett, T.S, Eck, M.J. Deposit date: 2022-03-10 Release date: 2022-11-23 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.42 Å) Cite: Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19. J.Med.Chem., 65, 2022
创建时间：
2022-03-10
