Sequencing analysis of the novel AGBE base editor

NIAID Data Ecosystem2026-03-13 收录

碱基编辑器评估

基因编辑安全性

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA824995 数据链接链接失效反馈

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资源简介：

Analyzing the effectiveness and off-target feature of the new base editor, AGBE.

创建时间：

2022-04-09

FNLS-YE1 induces no sgRNA-independent off-target effect in human embryos

基因编辑安全性

人类胚胎基因编辑

We performed whole-genome sequencing (WGS) on human embryonic stem cells derived from human 8-cell embryos injected with or without FNLS-YE1, together with sgRNA that targeting PCSK9. Blood cell genom

NIAID Data Ecosystem90

Table_3_Gene Editing and Genotoxicity: Targeting the Off-Targets.XLSX

基因编辑安全性

脱靶效应检测

Gene editing technologies show great promise for application to human disease as a result of rapid developments in targeting tools notably based on ZFN, TALEN, and CRISPR-Cas systems. Precise modifica

NIAID Data Ecosystem80

High-throughput sequencing data of eeCas9 and eeBE of file6

基因编辑脱靶检测

碱基编辑器评估

Evaluation of the off-target efficiency of eeABEmax and ABEmax by HTS analysis in 293T cells.

NIAID Data Ecosystem60

No observable guide-RNA-independent off-target mutation induced by prime editor [RNA-Seq]

基因编辑安全性

全长转录组分析

Prime editor (PE) has been recently developed to induce efficient and precise on-target editing, whereas its guide RNA (gRNA)-independent off-target effects remain unknown. Here, we used whole-genome

NIAID Data Ecosystem90

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

基因编辑安全性

核酸酶脱靶检测

We describe a robust linear amplification-mediated high-throughput genome-wide translocation sequencing (HTGTS) method that identifies endogenous or ectopic "prey" DNA double-stranded breaks (DSBs) ac

NIAID Data Ecosystem70

Sequencing analysis of the novel AGBE base editor

资源简介：

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