Mutational analysis of measles virus suggests constraints on antigenic variation of the glycoproteins. Measles morbillivirus

RNAseq of mutant measles virus libraries Overall design: Insertional mutagenesis of measles to identify tolerated locations Mutant measles virus libraries were constructed as described in: Heaton, N.S., Sachs, D., Chen,C.J., Hai, R., and Palese, P. (2013). Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins. PNAS. 110, 20248-20253.