The prostate cancer androgen receptor cistrome in African American men differs from White men and associates with upregulation of lipid metabolism [EA]

We use androgen receptor chromatin immunoprecipitation (AR ChIP) on frozen prostate adenocarcinoma samples and normal prostate counterparts in men of European ancestry as well as men of African (AA) ancestry and derive a model whereby increased androgen signaling drives higher levels of lipogenesis in AA prostate tumors. Overall design: Examination of the androgen receptor cistrome in prostate adenocarcinomas and normal prostate tissue derived men of European ancestry