DNA methylation analysis of astroblastomas

Astroblastomas represent rare cerebral tumors of the central nervous system (CNS). The status of astroblastoma as a distinct molecular entity is controversial, largely because the molecular features of astroblastomas have not been comprehensively evaluated. Herein, we used methylation profiling to compare the signatures of astroblastoma to a reference cohort of brain tumor entities. We found that astroblastomas are molecularly heterogenous and share molecular features with known brain tumor entities including plexomorphic xanthoastrocytoma, high-grade neuroepithelial tumor with MN1 abnormalities, as supratentorial ependymomas with RELA fusions. 23 unique astroblastomas were profiled using Illumina Infinium Human MethylationEpic Bead Array (n=23 total samples). The series includes re-analyzed data of 195 samples from GSE90496. The entire data matrix with the average beta values for all 218 analyzed samples is available at the foot of this page.