Qt-Igc Meta-Analysis Results

Meta-analysis results from the QT-IGC meta-analysis of QT interval duration. The manuscript detailing the generation and analysis of these results can be found here (https://www.nature.com/articles/ng.3014, Nature Genetics) and here (https://paperpile.com/shared/JEVaXW). Column names: SNP - SNP identifier (note that these will be on a much older dbSNP build!) CHR - Chromosome POS - Position, hg18 A1 - minor allele in HapMap 2 A2 - other allele in HapMap 2 HAPMAP_A1_FREQ - frequency of A1 in HapMap CODED_ALLELE - the coded allele in the meta. All stats refer to this allele. NONCODED_ALLELE - other allele CODED_ALLELE_FREQ - frequency of the coded allele N_EFF - effective sample size Z_SQRTN - Z-score of the SNP in sample size meta-analysis P_SQRTN - P-value of the SNP in sample size meta-analysis BETA_FIXED - Beta of coded allele in fixed effects meta-analysis SE_FIXED - standard error of coded allele in fixed effects meta-analysis Z_FIXED - z-score of coded allele in fixed effects meta-analysis P_FIXED - p-value in fixed effects meta-analysis BETA_LOWER_FIXED - lower estimate of the beta, fixed effects BETA_UPPER_FIXED - upper estimate of the beta, fixed effects BETA_RANDOM - beta of coded allele in random effects meta-analysis SE_RANDOM - standard error of the coded allele in random effects meta-analysis Z_RANDOM - z-score from random effects meta-analysis P_RANDOM - p-value from random effects meta-analysis BETA_LOWER_RANDOM - lower estimate of the beta, random effects meta BETA_UPPER_RANDOM - upper estimate of the beta, random effects meta COCHRANS_Q - Cochran's test of heterogeneity, Q statistic DF - degrees of freedom for Cochran's Q test P_COCHRANS_Q - p-value of Cochran's Q test I_SQUARED - I-squared stat, test of heterogeneity TAU_SQUARED - Tau-squared, test of heterogeneity DIRECTIONS - directions of the beta in each of the cohorts used in meta-analysis. Cohorts are in the same order as in the params file provided in the related GitHub repo (https://github.com/saralpulit/QTIGCmeta) GENES_1000KB - Genes within 1000kb of the SNP, according to RefSeq NEAREST_GENE - Gene closest to the SNP, according to RefSeq FUNCTION - function of the SNP, if relevant CAVEAT - any relevant caveats, e.g., A/T or C/G SNPs with >40% minor allele frequency