mRNA-seq to test effect of PYK2 inhibitor (defactinib) on LPS induced gene expression in WT and IRF5-/- BMDMs
收藏NIAID Data Ecosystem2026-03-13 收录
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To investigate the specificity of Defactinib on IRF5 target genes we compare LPS-induced transcriptomes in WT and IRF5 KO BMDMs treated with either Defactinib or vehicle. Macrophage transcriptomic signature under PYK2 inhibition phenocopied IRF5 deficiency Overall design: unstimulated (DMSO treated) and LPS stimulated (DMSO or Defactinib treated) BMDMs from WT or IRF5-/- mice. 3 biological replicates per condition
创建时间：
2021-12-03
