Expression data from human neutrophils isolated from the peripheral blood of psoriasis patients and healthy controls

In psoriasis, neutrophils accumulate in the epidermis or scatter in the dermis, which may contribute to the inflammation by releasing a variety of cytokines, chemokines, as well as various enzymes and antimicrobe proteins (AMPs). However, the exact role of neutrophils needs to be further illustrated. To identify the differences between psoriasis neutrophils and healthy ones, we analyzed microarray expression data from 3 peripheral neutrophil samples of psoriasis patients and 3 samples of healthy controls. This study identifies that neutrophils are activated and regulated in psoriasis, and these DEGs may contribute to the development of psoriasis. We empolyed CD15 microbeads to isolate peripheral neutrophils of psoriasis patients and healthy controls (n = 3 for each group), and total RNA containing small RNA was extracted