ProbResist

Here, we describe the development of ProbResist, which is a manually curated online database that catalogs reports of probiotic bacteria that have been experimentally proven to be resistant to antibiotics. ProbResist allows users to search for information of drug resistance in probiotics by querying with the names of the bacteria, antibiotic or location. Retrieved results are presented in a downloadable table format containing the names of the antibiotic, probiotic species, resistant determinants, region where the study was conducted and digital article identifiers (PubMed Identifier and Digital Object Identifier) hyperlinked to the original sources. The webserver also presents a simple analysis of information stored in the database.本文详述了ProbResist数据库的构建流程：该数据库为人工整理筛选的在线资源库，收录经实验证实具有抗生素抗性的益生菌相关研究报道。用户可通过输入菌株名称、抗生素名称或研究地域进行查询，检索益生菌耐药性相关信息。检索结果将以可下载表格形式呈现，表格涵盖抗生素名称、益生菌物种、耐药决定因子、研究开展地区，以及可链接至原始文献的数字文献标识符，包括PubMed标识符（PubMed Identifier）与数字对象标识符（Digital Object Identifier）。该在线服务器同时提供数据库存储信息的简易分析功能。

搜集汇总

背景与挑战

背景概述

ProbResist是一个手动管理的在线数据库，专门收录实验证明具有抗生素耐药性的益生菌报告。用户可通过细菌名称、抗生素或位置进行搜索，结果以可下载表格形式提供，包含抗生素、益生菌物种、耐药决定因素、研究区域和文章标识符等信息，并支持简单的数据分析。