Triglyceride-glucose index and its additive interaction with ABCG2/SLC2A9 polygenic risk score on hyperuricemia in middle age and older adults: findings from the DLCC and BHMC study

We aim to investigate the joint effect of triglyceride-glucose (TyG) index and polygenic risk scores (PRS) of urate transporter genes ABCG2 and SLC2A9 on hyperuricemia. Baseline data from two prospective population-based cohort studies, including 30,453 individuals aged 50 years or older, were used to analyze the association between TyG index and hyperuricemia. A case-control study was then designed from the cohorts to investigate the interaction between genetic predisposition and TyG index on hyperuricemia among 595 matched pairs. PRS was constructed using 14 single nucleotide polymorphisms located in the ABCG2 and SLCA29 genes. In both sexes, higher TyG index levels were correlated with elevated serum urate (SUA) levels (p values in both sexes p values The impact of genetic predisposition on hyperuricemia was significantly greater among individuals with a higher TyG index. Over 50% of the increased risk can be attributed to the interaction, indicating a crucial synergy between genetic factors and TyG index when estimating hyperuricemia risk. There are both linear and non-linear relationships between TyG index and serum urates.Genetic predisposition on hyperuricemia was significantly greater among individuals with a higher TyG index.Over 50% of the increased risk of hyperuricemia can be attributed to the genetic-phenotype interaction. There are both linear and non-linear relationships between TyG index and serum urates. Genetic predisposition on hyperuricemia was significantly greater among individuals with a higher TyG index. Over 50% of the increased risk of hyperuricemia can be attributed to the genetic-phenotype interaction.