Structure of PIK3CA with covalent inhibitor 22
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Structure of PIK3CA with covalent inhibitor 22 Descriptor: N-[2-(4-{4-[2-amino-4-(difluoromethyl)pyrimidin-5-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}piperazin-1-yl)-2-oxoethyl]-N-methyl-1-(prop-2-enoyl)piperidine-4-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Authors: Burke, J.E, McPhail, J.A. Deposit date: 2021-06-29 Release date: 2022-04-06 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Covalent Proximity Scanning of a Distal Cysteine to Target PI3K alpha. J.Am.Chem.Soc., 144, 2022
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2021-06-29
