Stem cell derived human microglia transplanted in mouse brain to study human disease
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
下载链接：
http://data.iscr.ac.cn/Article?id=13ea40ea09ede86e8bc7cdfaa5ca56b1
下载链接
链接失效反馈官方服务：
资源简介：
While genetics highlight the role of microglia in Alzheimerâs disease (AD), one third of putative AD-risk genes lack adequate mouse orthologs. Here, we successfully engraft human microglia derived from embryonic stem cells in the mouse brain. The cells recapitulate transcriptionally human primary microglia ex vivo and show expression of human specific AD-risk genes. Oligomeric Amyloid-β induces a divergent response in human vs. mouse microglia. This model can be used to study the role of microglia in neurological diseases.
提供机构：
VIB
创建时间：
2022-02-20
