HFE binds TFRC dimer

Transferrin, in dimeric form (TFRC dimer), mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. Hereditary hemochromatosis protein (HFE) binds to TFRC dimer and reduces its affinity for iron-loaded transferrin (Feder et al. 1998).

转铁蛋白（Transferrin）以二聚体形式（TFRC dimer）存在，通过非铁依赖途径介导细胞对转铁蛋白结合铁的摄取。遗传性血色素沉着病蛋白（Hereditary hemochromatosis protein，HFE）与TFRC二聚体结合，降低其对负载铁的转铁蛋白（Feder et al. 1998）的亲和力。