RNAseq analysis of mouse monocytes exposed to IL4 ex vivo. RNAseq analysis of mouse monocytes exposed to IL4 ex vivo

Immune cells can rapidly adapt their functional program in response to cytokines. How cytokine-induced transcriptional responses are affected by micro-environmental cues remains poorly understood. The Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor sensing environmental signals including metabolites. Here we addressed the cross-talk between Interleukin-4 and AhR signaling in monocytes. Overall design: We analysed the transcriptome of mouse monocytes (wild-type or deficient for AhR) to IL-4 after 3h of ex vivo exposure.