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Anti-CD25 Treg targeting antibodies sparing IL-2 signaling promote regression of established glioblastoma tumors and innate cell activation.

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NIAID Data Ecosystem2026-05-02 收录
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Treg depletion in mouse GBM using the anti-CD25 antibody, led to tumor regression and improved survival. We performed single cell RNA sequencing on tumor, lymphoid and myeloid samples from treated and untreated samples Overall design: Myeloid, lymphoid and tumor/stroma cells were isolated using fluorescence-activated cell sorting based on the expression of CD45 and CD11b

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2025-05-13
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