Candidate genes in selected regions (FST).

Candidate genes located within regions that have been subject to positive selection in Thoroughbred ranked by FST; the locus with the strongest evidence for selection is listed first. Heterozygosity values for Thoroughbred (TB), Akhal-Teke (AH), Connemara (CON) and Tuva (TU) are shown. Loci with lowest heterozygosity in Thoroughbred were included. Loci were localised to chromosomes and their positions were determined by in silico ePCR (Table S1). Each selected region was defined by loci flanking the central locus. Dh/sd scores and associated P-values for Thoroughbred are given to indicate within population deviation from expected heterozygosity. Four loci (TKY222, TKY033, NVHEQ079 and TKY316) had highly significant (PAHT024, UMNe197, COR032, TKY303 and VHL150) met a less stringent criteria (PNS) from expected heterozygosity in the Ewens-Watterson test. The number of genes (with Homo sapiens functional annotation) located within each defined region is given. Two regions (defined by HTG009 and COR032) were considered too large (39 Mb and 36 Mb) to reasonably search for candidate genes, however LEP (Leptin), associated with obesity in mouse [137], is located at 83.4 Mb on ECA4. COR032 is located adjacent to NVHEQ079 and UM176 on ECA17 together defining a 48 Mb region that may contain a number of strongly selected genes.