<strong>Network Interaction of The Mechanism Effect of Phytoconstituents Spirulina platensis on Cardiovascular Premature Senescence to Cigarette Smoke Exposure</strong>

Cardiovascular premature senescence may be induced by cigarette smoke exposure due to the limited cardiac regeneration capacity which is mainly caused by excessive oxidative stress and chronic low-grade inflammation. There is evidence that tobacco smoking is an important factor contributing to premature vascular aging, which can be treated by lipid-lowering, anti-inflammatory, anticoagulant, antiplatelet, antihypertensive, and vasodilator with the prolonged use of these drugs brings a series of problems. Using herbal medicine, one of with Spirulina platensis, an Indonesia`s marine natural products for medical use, may be used as an anti-inflammatory.