Neurological impairment and integrity of the BBB.
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https://figshare.com/articles/dataset/_Neurological_impairment_and_integrity_of_the_BBB_/225630
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Groups of 3 Plasmodium-infected mice, unless otherwise indicated, were injected with Evans blue at first sign of ECM (typically on day 6 after infection) or at a parasitemia exceeding 50% (typically on day 5), and sacrificed three hours later by exsanguination under anesthesia. Brains were extracted with formamide and vascular leakage was determined by measuring Evans blue absorption at 620 nm (OD620).
***P<0.001,
**P<0.01,
*P<0.05 indicate a significant increase in BBB permeability. Data were analyzed separately within each mouse strain by one-way ANOVA followed by Dunnett's test for comparisons with a control.
§Two PbA-infected A/J mice displayed elevated OD620 values, but no neurological signs.
创建时间：
2012-10-25
