Overview of structures and yields of intermediates 3 and 4 (shown in “S1 Fig.”) and analogs 5 (as described in “Supporting Information”) with PKD1 inhibition data for analogs 5.
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aPiperazine is directly connected to the pteridine core without a secondary amine.bVia the PyBOP route.cVia the chlorination/substitution route (2-step yield).Overview of structures and yields of intermediates 3 and 4 (shown in “S1 Fig.”) and analogs 5 (as described in “Supporting Information”) with PKD1 inhibition data for analogs 5.
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2015-12-03
