Metal-Free Synthesis of Indole via NIS-Mediated Cascade C–N Bond Formation/Aromatization

A novel
rapid synthesis of indoles from N-Ts-2-alkenylanilines
has been described; the reaction involves a NIS-mediated cascade C–N
bond formation/aromatization, and a series of indoles with various
functional groups have been synthesized in good to excellent yields
under mild conditions without any other additives or catalysts.

本研究报道了一种新型快速合成吲哚的方法，该方法以N-Ts-2-烯丙基苯胺为原料，通过NIS介导的级联C-N键形成/芳构化反应实现；在温和条件下，无需添加其他助剂或催化剂，成功合成了多种具有不同官能团的吲哚，其产率优良至极。