DEEP CHARACTERIZATION OF PAIRED CHROMATIN AND TRANSCRIPTOMES IN FOUR IMMUNE CELL TYPES FROM MULTIPLE SCLEROSIS PATIENTS

<b>Supplementary Figure 1: Overview of the data analysis pipeline</b> <b> </b> <b>Supplementary Figure 2: </b>Volcano plots showing differentially expressed (DE) genes between HC and RR in CD4, CD8, CD14, and CD19. DE analysis was performed on all genes using linear models that, in addition to disease status, included age as a covariate (Methods). DE genes (FDR=0.2) have been highlighted with blue if upregulated in RR and red if downregulated in RR. <b></b> <b> </b> <b>SUPPLEMENTARY TABLES:</b> <b>Supplementary table 1:</b> ATAC Seq differentially bound regions in all 4 cell types <b>Supplementary table 2:</b> Transcription factor enrichment <b>Supplementary table 3:</b> RNA Seq differentially expressed genes <b>Supplementary table 4:</b> Correlation of differentially expressed and differentially bound regions