Survival of heart grafts transplanted to irradiated BMT recipients at day 100 after BMT (after T cell regeneration of recipients).

The experimental groups are named according to the pre-treatment. Heart graft donors differed in all MHC antigens from recipients and in MHC class I antigens from the BMC donors. Control groups consist of naïve recipients receiving completely MHC disparate grafts (MHC I + II) or solely MHC class I disparate grafts (MHC I). Mean percentages of chimerism in blood are given at day 14 and day 100 after BMT. Survival of each single heart graft and mean survival times for each group (MST) are given. Statistical analyses were performed using two-sided, unpaired student´s t-test. Each group was compared with the 6 Gy control group (n.s. = not significant). Additional statistical tests showed that * transient chimeras treated with Srl (6 Gy BMT Srl (14 days)) accepted heart grafts significantly longer than transient chimeras treates with CsA (6 Gy BMT CsA (14 days)) (p = 0.047). # Prolonged Srl application resulted in significantly longer heart graft acceptance (6 Gy BMT Srl (28 days) vs. 6 Gy BMT Srl (14 days) (p < 0.001).
Survival of heart grafts transplanted to irradiated BMT recipients at day 100 after BMT (after T cell regeneration of recipients).