Dataset for: Radiation therapy induces innate immune responses in patients treated for prostate cancers

Purpose
Radiation therapy (RT) is a curative therapeutic modality used to treat cancers as a single agent or in combination with surgery and chemotherapy. Advanced RT technologies enable treatment with large fraction, highly conformal, radiation doses to effect free-radical damage to cellular DNA leading to cell cycle arrest, cell death, and innate immune response stimulation.
Experimental Design
To understand systemic clinical responses after radiation exposure, high throughput proteomic and metabolomic analyses were performed on plasma obtained from cancer patients at intervals after prostate stereotactic body radiation therapy. Pathway analysis and multivariate analyses were used to delineate molecular alterations following radiation therapy and its correlation with clinical outcomes.
Results
DNA Damage Response (DDR) and cell cycle signaling increased within the first hour after treatment and returned to baseline by one month. Innate immune response signaling also increased within..., ,