Recurrent glioblastoma (GBM) has a grim prognosis, though MGMT promoter methylation and IDH mutation provide a significant survival advantage. The product of IDH mutation, 2-hydroxyglutarate, increas

NIAID Data Ecosystem60

Differential gene expression of neuroblastoma cells stably expressing doxycycline-inducible DOT1L small hairpin RNA. Homo sapiens

母细胞瘤表观遗传学

DOT1L敲低效应

We were interested in studying the role of DOT1L-mediated H3K79 methylation on N-Myc target gene transcription in MYCN-induced neuroblastoma. We aimed to determine whether knocking down DOT1L in MYCN-

NIAID Data Ecosystem30

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin [expression]

母细胞瘤表观遗传学

干细胞自我更新

Mutations in the histone 3 variant H3.3 have been identified in one-third of pediatric glioblastomas (GBMs), but not in adult tumors. Here we show that H3.3 is a dynamic determinant of functional prop

NIAID Data Ecosystem60

EGFR Mutation Promotes Glioblastoma Through Epigenome and Transcription Factor Network Remodeling

母细胞瘤表观遗传学

EGFR突变致癌机制

Epidermal Growth Factor Receptor (EGFR) gene amplification and mutations are the most common oncogenic events in Glioblastoma (GBM), but the mechanisms by which they promote aggressive tumor growth ar

NIAID Data Ecosystem30

GSM8112028_SKNAS-ABE24_3_R1.bigWigNeuroblastoma cell lines

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