DataSheet1_Design and Synthesis of Conformationally Diverse Pyrimidine-Embedded Medium/Macro- and Bridged Cycles via Skeletal Transformation.pdf
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https://figshare.com/articles/dataset/DataSheet1_Design_and_Synthesis_of_Conformationally_Diverse_Pyrimidine-Embedded_Medium_Macro-_and_Bridged_Cycles_via_Skeletal_Transformation_pdf/19514119
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资源简介：
The rigidity and flexibility of small molecules are complementary in 3-dimensional ligand-protein interaction. Therefore, the chemical library with conformational diversity would be a valuable resource for investigating the influence of skeletal flexibility on the biological system. In this regard, we designed and synthesized ten conformationally diverse pyrimidine-embedded medium/macro- and bridged cyclic scaffolds covering 7- to 14-member rings via an efficient skeletal transformation strategy. Their high conformational and shape diversity was confirmed by chemoinformatic analysis.
创建时间：
2022-04-04
