NHLBI TOPMed: Children's Health Study (CHS) Integrative Genomics and Environmental Research of Asthma (IGERA)

The Integrative Genomics and Environmental Research of Asthma (IGERA) Study was proposed to collect immortalized cell lines, RNA, cDNA and DNA from 400 well-characterized subjects who participated in the southern California Children's Health Study (CHS) and to develop an accompanying database for these samples consisting of extensive phenotype, exposure, genome-wide genotype, gene expression, and methylation data. A subset of Hispanic-White participants (n=160) were included in the TOPMed project, including 77 asthma cases and 83 controls.]]>
TOPMed Whole Genome Sequencing Methods: Freeze 9TOPMed Whole Genome Sequencing Methods: Freeze 10Inclusion criteria: Former participants in the southern California Children's Health Study (CHS) Hispanic and non-Hispanic whites Provides consent to provide biological sample and other data for the formation of biorepository. Exclusion criteria: Those who do not sign the informed consent form Does not have GWAS data Ethnic groups other than Hispanic or non-Hispanic whites ]]>
Enrollment Years IGERA: April 2010 to Dec 2011]]>