In the cell, stalled ribosomes are rescued through ribosome-associated protein quality-control (RQC) pathways. We demonstrate that RqcH is responsible for tRNAAla selection during RQC elongation, wher

NIAID Data Ecosystem60

A virtuous cycle operated by ERp44 and ERGIC-53 guarantees proteostasis in the early secretory compartment

细胞生物学

蛋白质质量控制

The composition of the secretome depends on the combined action of cargo receptors that facilitate protein transport and sequential checkpoints that restrict it to native conformers. Acting after endo

Mendeley Data2024-03-27 更新50

MOESM2 of Quality control of imbalanced mass spectra from isotopic labeling experiments

同位素标记

蛋白质质量控制

Additional file 2 This is a four-sheet xls file (7180KB) containing the TPP analysis results and extracted features, each sheet refers to one dataset with special ratio in its sheet name, e.g., 1_1 is

NIAID Data Ecosystem60

ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD

神经退行性疾病

蛋白质质量控制

C9ORF72-derived dipeptide repeat proteins have emerged as the pathogenic cause of neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). However, the mechanisms u

Mendeley Data2024-03-27 更新60

The Dfm1 derlin is required for ERAD retrotranslocation of integral membrane proteins, Neal et al

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