Inhibitory activity of human and guinea pig sera depleted of PLY antibodies.

Shown are the average EC50 values, SD and fold-change in EC50 values for PLY treated with complete human or guinea pig sera or PLY-antibody depleted sera. The fold change = EC50 in the presence of serum/EC50 in PBS. Results from 3 independent assays are shown. Note that PLY antibody titers can vary in various lots of serum: hence, the sera analyzed for antibody here are different lots than those used in Table 1. This human serum sample displayed a higher anti-PLY titer than that shown in Table 1 (refer to Table S1). Inhibitory activity of human and guinea pig sera depleted of PLY antibodies.