Computational modelling for improved translation of cardiac inotropic and lusitropic drug effects from rats to humans

The dataset in this repository includes experimental measurements (sarcomere length and fluorescence intensity ratio) from unloaded, contracting left ventricular rat cardiomyocytes, as well as simulation results (sarcomere length and intracellular calcium concentration) from calibrated rat and human left ventricular cardiomyocyte models. The experimental data consist of three subsets: dataset #1 was collected at a pacing frequency of 1 Hz; dataset #2 at pacing frequencies of 0.5, 1, and 2 Hz; and dataset #3 at 1 Hz before and after thapsigargin administration at four concentrations. The simulation data were generated as part of the evaluation of the computational drug effect translation approach introduced in the related journal article, using both experimental data (administration of thapsigargin) and synthetic data (administration of 100 virtual drugs).