Expression of DLL3 in paraxial mesoderm

Delta-like 3 (DLL3) is a divergent Delta-like gene that encodes an inhibitory ligand of NOTCH. DLL3 is expressed in the primitive streak and the entire mesoderm, then becomes restricted to the paraxial mesoderm at the late primitive streak stage.(inferred from the mouse homolog). A mutation in DLL3 can disrupt somitogenesis and cause severe rib and vertebral deformities (inferred from the mouse pudgy mutant).

DLL3（Delta-like 3）是一种与Delta样基因不同的Delta样基因，其编码的为NOTCH的抑制性配体。DLL3在原始条和整个中胚层中表达，随后在原始条晚期阶段限制性表达于旁轴中胚层（根据小鼠同源基因推断）。DLL3基因的突变可能破坏节形成过程，并导致严重的肋骨和椎骨畸形（根据小鼠肥胖突变体推断）。