Phospho-JAK2 phosphorylates EPOR

Phosphorylated JAK2 phosphorylates 8 tyrosine residues in the cytoplasmic tail of EPOR (Dusanter-Fourt et al. 1992, McGraw et al. 2012, and inferred from mouse homologs). The phosphorylated residues then serve as binding sites for scaffold proteins such as CRKL and GAB1 and downstream signaling proteins such as STAT5, phospholipase C, and phosphatidylinositol 3-kinase.

磷酸化的 JAK2 在 EPOR 的胞浆尾部磷酸化 8 个酪氨酸残基（Dusanter-Fourt 等人，1992年；McGraw 等人，2012年；并从小鼠同源物中推断得出）。这些磷酸化的残基随后作为支架蛋白如 CRKL 和 GAB1 以及下游信号蛋白如 STAT5、磷脂酶 C 和磷脂酰肌醇 3-激酶的结合位点。