Doxorubicin is a widely used chemotherapeutic drug that intercalates between DNA base-pairs and posions Topoisomerase II, although the mechanistic basis for cell killing remains speculative. Here we s
White adipose tissue (WAT) plays a fundamental role in maintaining energy balance and important endocrine functions. The loss of WAT modifies adipokine secretion and disrupts homeostasis, potentially
Cyclophosphamide is a nitrogen mustard derivative that becomes active through hydrolysis by excessive cytochrome P450 enzymes or phosphatases in the liver or tumor, transforming into its active form.
