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Synthesis of 7a-Substituted Hajos−Wiechert Ketone Analogues

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https://figshare.com/articles/dataset/Synthesis_of_7a_Substituted_Hajos_Wiechert_Ketone_Analogues/2929798
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A general and efficient route to 2-substituted 1,3-cyclopentadiones 3 has been developed. This operationally simple, two-step procedure is amenable to multigram scale preparations of these useful synthetic intermediates. These compounds are then transformed to previously unknown, higher analogues of the Hajos−Parrish−Eder−Sauer−Wiechert ketone (enone 1, R = Me) following an enantioselective Robinson annulation.
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2016-02-27
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