Avon Longitudinal Study of Parents and Children

ALSPAC is a longitudinal birth cohort study which enrolled pregnant women who were resident in one of three Bristol-based health districts in the former County of Avon with an expected delivery date between 1st April 1991 and 31st December 1992. Around 14,000 pregnant women were initially recruited. Detailed information has been collected on these women, their partners and subsequent children using self-completion questionnaires, data extraction from medical notes, linkage to routine information systems and from hands-on research clinics. Additional cohorts of participants have since been enrolled in their own right including fathers, siblings, children of the children and grandparents of the children. Ethical approval for the study was obtained from the ALSPAC Ethics and Law Committee (IRB00003312) and Local Research Ethics.

ALSPAC是一项纵向出生队列研究，招募了居住在原艾冯郡的布里斯托尔三个卫生区域内的孕妇，她们的预产期在1991年4月1日至1992年12月31日之间。最初共有约14,000名孕妇被招募。通过对这些妇女、她们的伴侣及后续子女进行自填问卷收集、从医疗记录中提取数据、与常规信息系统对接以及实地研究诊所的参与，收集了关于她们及其家庭的详细信息。此后，还招募了额外的参与者群体，包括父亲、兄弟姐妹、子女的子女以及子女的祖父母。研究获得了ALSPAC伦理和法律委员会（IRB00003312）以及当地研究伦理委员会的伦理批准。