Diversity-Oriented Synthesis of Steviol Glycosides

With
cheap and easily available mixtures of steviol glycosides
as starting materials, a practical method for steviol acquisition
has been developed, on the basis of which a facile, diversity-oriented,
and economic protocol for the synthesis of structurally defined steviol
glycosides was established. The novel approach is featured by the
highly efficient glycosylation of sterically hindered and acid-sensitive
steviol via orchestrated application of Yu glycosylation, Schmidt
glycosylation, and PTC glycosylation. Hence, these high-intensity
sweeteners and potential lead compounds for drug development are now
readily accessible.