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Inhibition of signaling of various Notch1-ligand pairs by Notch1 antibodies.

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https://figshare.com/articles/dataset/_Inhibition_of_signaling_of_various_Notch1_ligand_pairs_by_Notch1_antibodies_/536044
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aLBD: EGF-like repeats (1–13) encompassing the ligand-binding domain; NRR: Negative regulatory region. bCo-culture assay with Notch1-Gal4 T-REX-U2OS cells transfected with UAS-luciferase reporter and Flp-In-3T3 cells overexpressing the ligands Jag2, Jag1, DLL1, and DLL4, respectively; normalized to signal obtained with Flp-In-3T3 parental cell line; average and standard deviation from at least 4 independent experiments. cInflection points poorly defined.
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2010-02-08
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