Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation

ChEBI2014-03-21 更新2026-07-21 收录

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基因突变功能

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-54611 数据链接链接失效反馈

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Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation

创建时间：

2014-03-21

ErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [ChIP-seq]

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Lung cancer remains the leading cause of cancer death. Genome sequencing of lung tumors from patients with Squamous Cell Carcinoma has identified SMAD4 to be frequently mutated. Here we used a novel m

NIAID Data Ecosystem90

Autoinhibited BRAF:(14-3-3)2:MEK complex with the BRAF RBD resolved

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靶向药物设计

Autoinhibited BRAF:(14-3-3)2:MEK complex with the BRAF RBD resolved Descriptor: 14-3-3 protein zeta/delta, Dual specificity mitogen-activated protein kinase kinase 1, N-(3-fluoro-4-{[4-methyl-2-oxo-7-

Protein Data Bank Japan2025-05-28 更新60

Identification of a novel TINCR-EGFR signaling pathway loop which initiates receptor tyrosine kinases cascade and confers tumorigenesis in human cancer

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肿瘤发生机制

RNA sequencing was performed to investigate the potential crosstalk between TINCR and microRNAs. Overall design: microRNA profiles of T47D with TINCR knockdown and scramble were generated by deep sequ

NIAID Data Ecosystem50

Additional file 4: Table S3. of Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3

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药物敏感性机制

Results of gene set enrichment analysis (GSEA) of the obtained three gene expression profiles of differences between sensitive and insensitive lung cancer cell lines. For that we used geneXplain platf

Figshare2018-02-14 更新60

Additional file 4: of Sunitinib-suppressed miR-452-5p facilitates renal cancer cell invasion and metastasis through modulating SMAD4/SMAD7 signals

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Table S4. miR-452-5p expression in RCC and normal renal samples from TCGA RCCÂ dataset. (XLS 137Â kb)

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