Number of Transmitted/Founder (T/F) viruses.

AMinimum estimates of the number of T/F viruses for 7B2 IgG and palivizumab IgG treated rhesus macaques are shown. At a mean of 60 sequences per animal, there is 95% confidence that all variants that are >5% in prevalence have been enumerated. *The difference in T/F variants between the 7B2 IgG_AAA treated animals and the negative control animals palivizumab IgG was statistically significant, p = 0.01; Mann-Whitney rank sum test, two tailed. B Minimum estimates of the number of T/F viruses for A32 IgG_AAA mAb and palivizumab IgG mAb treated rhesus macaques are shown. At a mean of 37 sequences per animal, there is 95% confidence that T/F variants with >8% prevalence in the population are represented. *The difference in T/F variants between the A32 IgG_AAA treated animals and the negative control animals palivizumab IgG was statistically significant, p = 0.033; Mann-Whitney rank sum test, two tailed. C Minimum estimates of the number of T/F viruses for CH22 IgG_AAA mAb and CH65 IgG mAb treated rhesus macaques. *The difference in T/F variants between the CH22 IgG_AAA treated animals and the negative control animals CH65 IgG was statistically significant, p = 0.011; Mann-Whitney rank sum test, two tailed. Number of Transmitted/Founder (T/F) viruses.