A clinical study to compare two techniques of pain relief(intravenous through blood route vs epidural through a catheter in back) after surgery for cancer treatment using reduction of tumour mass and chemotherapy at high temprature

Intervention1: Intravenous local anaesthetic and opioid infusion: Bolus dose of 1.5 mg/kg lignocaine over 15 mins, starting approximately 15 mins before surgical incision and fentanyl 0.5 mcg/kg, approximately 2 min before surgical incision will be administered. Following this patient will be receiving lignocaine infusion at 1 mg/kg/hr and fentanyl infusion at 0.5 mcg/kg/hr intraoperatively.
Control Intervention1: Epidural Ropivacaine and fentanyl infusion: epidural catheter will be placed as per incision congruent technique before induction. Placement of the catheter will be checked by 3 ml of 2% lignocaine with adrenaline (1:200000). Epidural analgesia will be activated by 6 ml of Ropivacaine 0.2% and fentanyl (2 mcg/ml) approximately 15 min before surgical incision.
Primary outcome(s): To evaluate postoperative analgesic efficacy of the analgesic technique.Timepoint: Immediately after extubation, 1 hour, 2 hour, 4 hour, 8 hour, 12 hour, 18 hour and 24 hour.
Study Design: Randomized, Parallel Group, Active Controlled Trial
Method of generating randomization sequence:Computer generated randomization Method of allocation concealment:Sequentially numbered, sealed, opaque envelopes Blinding and masking:Participant Blinded