Is retina affected in Huntington's disease? Is optical coherence tomography a good biomarker?

Prospective cross-sectional measurement of peripapillary retinal nerve fiber layer thickness (RNFL) and total macular volume (TMV) measured by spectral domain optical coherence tomography (OCT) of retina, Pelli-Robson Contrast Sensitivity test, Farnsworth 15 Hue Color discrimination test, and Unified Huntington’s disease Rating Scale (UHDRS).
, Patients were assessed by Unified Huntington's disease Rating Scale (UHDRS). Pelli-Robson Contrast Sensitivity test Chart 4K, which uses a single large letter size (20/60 optotype) with contrast varying across groups of letters, was used to evaluate Contrast Sensivity. A Pelli-Robson score of 1.5 to 2.25 indicates normal Contrast Sensitivity, a score of 0.9 to 1.35 indicates moderate contrast loss, a score of 0.3 to 0.75 severe contrast loss and a score of 0.15 and less indicates profound contrast loss. Farnsworth D-15 Color test was performed to evaluate Color Discrimination. The results of the Farnworth D-15 test determine color perception or defects in deutan, protan or tritan discrimination.
Using a spectral-domain OCT machine (Heidelberg Spectralis), without pupil dilation, we obtained a circular scan manually centered on the optic nerve head (diameter 3.4mm, Automated Real-Time - ART 100) and a macular volume scan centered on the fovea (63 lines, ART 20). The thickness of the peri..., , # Data from: Is retina affected in Huntington's disease? Is optical coherence tomography a good biomarker?

[https://doi.org/10.5061/dryad.ncjsxksxr](https://doi.org/10.5061/dryad.ncjsxksxr)

## Description of the data and file structure

OCT measurement of patients with Huntington's disease.

### Files and variables

#### File: data.csv

**Description:** OCT Measurements in Huntington's Disease and Healthy Controls

##### Variables:

* record_id: unique id of a subject
* group: whether the subject is in Huntington's Disease patient group or healthy controls group
* gender: gender of the subject
* age: age range group of the subject at the time of OCT measurement in years
* visit: number of visit (first or second measurement)
* disease_length: disease length range group at the time of OCT measurement in years. 'NA' means 'not applicable', it is in healthy conrols that do not have the disease.
* triplet_longer: CAG repeat number. 'NA' means 'not applicable', healthy controls do not have ..., The patients consented with de-identified data publication. For identifiable fields, only ranges (e.g. for age and disease length) are published.