Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.
收藏PubMed Central1996-09-03 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC38493/
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资源简介：
Chimeric mice in which lymphocytes are deficient in the Syk tyrosine kinase have been created. Compared with Syk-positive controls, mice with Syk -/- lymphocytes display substantial depletion of intraepithelial gamma delta T cells in the skin and gut, with developmental arrest occurring after antigen receptor gene rearrangement. In this dependence on Syk, subsets of intraepithelial gamma delta T cells are similar to B cells, but distinct from splenic gamma delta T cells that develop and expand in Syk-deficient mice. The characteristic associations of certain T-cell receptor V gamma/V delta gene rearrangements with specific epithelia are also disrupted by Syk deficiency. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-09-03
